Contact
valentin.dunsing 'at' univ-amu.fr
ORCID
google scholar

Biography

• 2021 - now Postdoc with PF. Lenne IBDM, Aix-Marseille University

• 2020 Postdoc with S. Chiantia, Cell Membrane Biophysics Group, University of Potsdam, Germany

• 2016-2020 PhD Thesis with S. Chiantia, Cell Membrane Biophysics Group, University of Potsdam, Germany

• 2012-2015 MSc Studies in Physics, Humboldt-University of Berlin, Germany and University of British Columbia, Vancouver, Canada
  MSc Thesis with A. Herrmann and S. Chiantia, Molecular Biophysics Group, HU Berlin, Germany
  Research Project with D. Coombs, Applied Mathematics Group, UBC, Vancouver, Canada

• 2009-2012 BSc Studies in Physics, Humboldt-University of Berlin, Germany
  BSc Thesis with A. Saez, Modern Optics Group, HU Berlin, Germany

Main research interest

Biological systems are highly dynamic. My research aims to understand how multicellular organization emerges from the dynamics and interactions of its constituents, on the molecular, cellular and tissue scale. To this aim, I apply and develop optical microscopy approaches such as 3D live imaging based on lightsheet microscopy and quantitative fluorescence techniques such as fluorescence fluctuation spectroscopy to observe molecular and cellular dynamics in living systems.

Current projects

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Publications

• Benchmarking of novel green fluorescent proteins for the quantification of protein oligomerization in living cells
  Petrich, A., Koikkarah Aji, A., Dunsing, V., Chiantia, S., bioRxiv 2023.02.07.527542; doi: https://doi.org/10.1101/2023.02.07.527542

• Technical insights into fluorescence lifetime microscopy of mechanosensitive Flipper probes
  Chloé Roffay, C., García-Arcos, JM., Chapuis, P., López-Andarias,J., Schneider, F., Colom, A., Tomba, C., Di Meglio, I., Dunsing, V., Matile, S., Roux, A., Mercier, V. (2022) bioRxiv 2022.09.28.509885; doi: https://doi.org/10.1101/2022.09.28.509885

• Biomimetic asymmetric bacterial membranes incorporating lipopolysaccharides
  Stephan, M., Dunsing, V., Pramanik, S., Chiantia, S., Barbirz, S., Robinson, T., Dimova, R. (2022). Biophysical Journal, 2022 Dec 15;S0006-3495(22)03927-3. doi: 10.1016/j.bpj.2022.12.017.

• Mandipropamid as chemical inducer of proximity for in vivo application and protein network manipulation
  Ziegler, M.J., Yserentant, K., Dunsing, V., Middel, V., Gralak, A.J., Pakari, K., Bargstedt, J., Kern, C., Petrich, A, Chiantia, S., Strähle, U., Herten, D-P., Wombacher, R. (2022). Nature Chemical Biology, 18(1), 64-69

• Influenza A M2 recruits M1 to the plasma membrane: a fluorescence fluctuation microscopy study
  Petrich, A., Dunsing, V., Bobone, S., Chiantia, S. (2021). Biophysical Journal, Volume 120, Issue 4, Pages 5478-5490

• Multi-color fluorescence fluctuation spectroscopy in living cells via spectral detection
  Dunsing, V.#, Petrich, A., Chiantia, S.# (2021). eLife 2021;10:e69687. #co-corresponding authors

• Pantoea stewartii WceF is a glycan biofilm modifying enzyme with a bacteriophage tailspike-like fold
  Irmscher, T., Roske, Y., Gayk, I., Dunsing, V., Chiantia, S., Heinemann, U., Barbirz, S. (2021). Journal of Biological Chemistry 296 100286

• Purely polysaccharide-based biofilm matrix provides size-selective diffusion barriers for nanoparticles and bacteriophages
  Dunsing, V., Irmscher, T., Barbirz, S., Chiantia, S. (2019). Biomacromolecules 20, 3842-3854.

• A fluorescence fluctuation spectroscopy assay of protein-protein interactions at cell-cell contacts
  Dunsing, V., Chiantia, S. (2018). Journal of Visualized Experiments (142), e58582.

• Optimal fluorescent protein tags for quantifying protein oligomerization in living cells
  Dunsing, V.#, Luckner, M.#, Zühlke, B., Petazzi, R.A., Herrmann, A., Chiantia, S. (2018). Scientific Reports 8:10634. #shared first authors

• Direct evidence of amyloid precursor-like protein 1 trans interactions in cell-cell adhesion platforms investigated via fluorescence fluctuation spectroscopy
  Dunsing, V., Mayer, M., Liebsch, F., Multhaup, G., Chiantia, S. (2017). Molecular Biology of the Cell 28, 3609-3620.

• Phosphatidylserine lateral organization influences the interaction of influenza virus matrix protein 1 with lipid membranes
  Bobone, S., Hilsch, M., Storm, J., Dunsing, V., Herrmann, A., Chiantia, S. (2017). Journal of Virology 91:e00267-17.

• Amyloid precursor-like protein 1 (APLP1) exhibits stronger zinc-dependent neuronal adhesion than amyloid precursor protein and APLP2
  Mayer, M. C., Schauenburg, L., Thompson-Steckel, G., Dunsing, V., Kaden, D., Voigt, P., Schaefer, M., Chiantia, S., Kennedy, T. E. and Multhaup, G. (2016). Journal of Neurochemistry, 137: 266-276.

• Design parameters for granzyme mediated cytotoxic lymphocyte target cell killing and specificity
  Woodsworth, D., Dunsing, V., Coombs, D. (2015). Biophysical Journal, Volume 109, Issue 3, Pages 477-488