Pierre Recouvreux
Biography
2013 - now University Lecturer
2010 - 2013 Postdoc with M. Dogterom, AMOLF, Amsterdam
2006 - 2010 PhD with JL Viovy, Institut Curie, Paris
2005 Agrégation de Physique
2002 - 2006 Physics student, ENS Lyon
Current work
I study different aspects of C. elegans embryo development using quantitative live imaging, simple modelling and numerical simulations. In collaboration with Vincent Bertrand at the IBDM, we focused on Wnt signalling. We looked at the distribution and dynamics of the ligand and its receptor in live embryos and tried to understand how signalling can occur on a timescale shorter than the cell cycle to direct the division axis of neuronal precursors. In collaboration with Ed Munro and JF Rupprecht we study the interplay between adhesion molecules and the actomyosin network during the formation of new cell-cell contacts in the early C. elegans embryo. We develop new microscopy approaches to image with high spatiotemporal resolution the formation of new contacts in the embryo.
Teachings
Physics of Living Systems, Fundamental Physics Master, AMU
Dynamics of Living Systems, Biology Master (2nd year), AMU
Microscopy, Biology Master (1st year), AMU
Optics and Electricity, L1 biology, Portail Pasteur, AMU
Publications
Recouvreux, P., Pai, P., Torro, R., Ludányi, M., Mélénec, P., Boughzala, M., Bertrand, V., and Lenne, P.-F. (2023). Establishment of Wnt ligand-receptor organization and cell polarity in the C. elegans embryo. BioRxiv, 2023.01.17.524363. 10.1101/2023.01.17.524363.
Kaur S, Mélénec P, Murgan S, Bordet G, Recouvreux P, Lenne PF, Bertrand V. Wnt ligands regulate the asymmetric divisions of neuronal progenitors in C. elegans embryos. Development. 2020 Apr 6;147(7):dev183186. doi:10.1242/dev.183186. PMID: 32156756.
Malabirade A, Partouche D, El Hamoui O, Turbant F, Geinguenaud F, Recouvreux P, Bizien T, Busi F, Wien F, Arluison V. Revised role for Hfq bacterial regulator on DNA topology. Sci Rep. 2018 Nov 14;8(1):16792. doi:10.1038/s41598-018-35060-9. PMID: 30429520; PMCID: PMC6235962.
Recouvreux P, Sokolowski TR, Grammoustianou A, ten Wolde PR, Dogterom M. Chimera proteins with affinity for membranes and microtubule tips polarize inthe membrane of fission yeast cells. Proc Natl Acad Sci U S A. 2016 Feb16;113(7):1811-6. doi: 10.1073/pnas.1419248113. Epub 2016 Feb 1. PMID: 26831106; PMCID: PMC4763754.
Recouvreux P, Lenne PF. Molecular clustering in the cell: from weak interactions to optimized functional architectures. Curr Opin Cell Biol. 2016 Feb;38:18-23. doi: 10.1016/j.ceb.2016.01.002. Epub 2016 Jan 30. PMID: 26829487.
Scheffler K, Recouvreux P, Paoletti A, Tran PT. Oscillatory AAA+ ATPase Knk1 constitutes a novel morphogenetic pathway in fission yeast. Proc Natl Acad Sci US A. 2014 Dec 16;111(50):17899-904. doi:10.1073/pnas.1407226111. Epub 2014 Nov 24. PMID: 25422470; PMCID: PMC4273388.
Nghe P, Boulineau S, Gude S, Recouvreux P, van Zon JS, Tans SJ.Microfabricated polyacrylamide devices for the controlled culture of growing cells and developing organisms. PLoS One. 2013 Sep 24;8(9):e75537. doi:10.1371/journal.pone.0075537. PMID: 24086559; PMCID: PMC3782435.
Recouvreux P, Dogterom M. Dissecting spindle architecture with a laser. Cell. 2012 Apr 27;149(3):507-9. doi: 10.1016/j.cell.2012.04.006. PMID: 22541422.
Recouvreux P, Lavelle C, Barbi M, Conde E Silva N, Le Cam E, Victor JM, Viovy JL. Linker histones incorporation maintains chromatin fiber plasticity. Biophys J. 2011 Jun 8;100(11):2726-35. doi: 10.1016/j.bpj.2011.03.064. PMID: 21641318; PMCID: PMC3117191.
Lavelle C, Recouvreux P, Wong H, Bancaud A, Viovy JL, Prunell A, Victor JM. Right-handed nucleosome: myth or reality? Cell. 2009 Dec 24;139(7):1216-7; author reply 1217-8. doi: 10.1016/j.cell.2009.12.014. PMID: 20064364.
Fuller DN, Gemmen GJ, Rickgauer JP, Dupont A, Millin R, Recouvreux P, Smith DE. A general method for manipulating DNA sequences from any organism with optical tweezers. Nucleic Acids Res. 2006 Feb 1;34(2):e15. doi: 10.1093/nar/gnj016. PMID: 16452295; PMCID: PMC1360288.